Antihypertensive efficiency and safety of L - & N-type Ca~(2+) antagonists -cilnidipine

摘要： <正> Objectives To evaluate antihypertensive efficiency and safety of a new domesticof L - & N - type Ca2+ antagonist - cilnidipine with imidapril as a positive control. Methods After 2 weeks' placebo washingout, 22 patients were treated with cilnidipine 5 mg daily and 27 patients were treated with imidapril 5 mg daily. 4 weeks later, if patient's sitting diastolic blood pressure is over 90 mmHg, his/ her dosage was doubled for another 4 weeks, the others measuring up remained their dosage unchanged for another 4 weeks. Blood pressure, heart rate, blood and urine routine examination, serum glucose, serum chemical examination including total cholesterol, triglyceride. HDL, LDL, transaminase, creatine etc and side reactions were recorded before and after the trial. Data were analyzed statistically. Results After 8 weeks' treatment, blood pressure was significantly decreased ( P < 0. 05) in both groups, and the two medicines had similar antihypertensive effects. Furthermore, the reducing of heart rate was stati ... （共6頁）